Tethered GPCR/Transducer Complexes for Scalable Drug Discovery and In Vitro Drug Screening (TRUPATH)

A suite of highly optimized heterotrimer-based BRET Gαßγ biosensors which robustly measure direct activation of non-visual G-proteins

English lab plasmid repository

Software written by the English lab members

An interactive visualization tool for exploring data from TRE MPRA experiments. Users may select different basal (unstimulated) and stimulated treatment conditions to compare transcriptional activity of thousands of synthetic promoters designed to respond to various cellular stimuli.

Github Entry

An interactive visualization tool for exploring data from deep mutation scanning (DMS) experiments. Users can select a protein and experimental condition to visualize how different amino acid mutations affect protein function or abundance. Users can compare mutation effects across conditions, sort amino acids by various properties (such as hydropathy, size, or polarity), and view or export mutation frequency data.